منابع مشابه
Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation.
UNLABELLED Genistein, a soybean-derived isoflavone, has been shown to suppress osteoclastic bone resorption. To clarify the mechanisms underlying this action, we investigated the effects of genistein on the differentiation, cytoskeleton and function in mice osteoclasts in vitro and bone metabolism in ovariectomized rats. STUDY DESIGN Primary OCs were isolated from 3 week-old mice and induced ...
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Colony-stimulating factors (CSF) active on five subgroups with different capacities to both human and murine bone marrow stimulate mouse granulocyte and macrocolony-forming units in culture (CFU-C) phage progenitors. CSF in these five peaks were found in the conditioned medium of were eluted from an Ultrogel AcA 44 gel Yoshida sarcoma cells (line YSSF-212T), filtration column withapparent molec...
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By WENDELL F. RossE, THOMAS WALDMANN AND ELEANOR Huu. H YPOXIA AND ANEMIA have been known for many years to stimulate erythropoiesis in mammals, including man.1 In recent years, these stimuli have been shown to have their effect through a humoral factor, erythropoietin.2 J acobson, et al. have suggested that lack of oxygen, relative to the metabolic needs of the animal, is the fundamental stimu...
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Muscle and bone anabolism and catabolism are tightly coupled during growth, development, and aging, yet the cellular and molecular mechanisms linking these two tissues are not well understood. Here we show that FGF-2 and IGF-1, two growth factors known to play a major role in regulating bone formation, are localized to muscle fibers along the muscle-bone interface of the mouse forelimb. Likewis...
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The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular. The former two subfamilies activate their signaling pathways through FGF receptors (FGFRs). Currentl...
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ژورنال
عنوان ژورنال: European Spine Journal
سال: 2001
ISSN: 0940-6719,1432-0932
DOI: 10.1007/s005860100269